IL18 and IL18R1 polymorphisms, lung CT and fibrosis: a longitudinal study in coal miners
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منابع مشابه
IL18 and IL18R1 polymorphisms, lung CT and fibrosis: A longitudinal study in coal miners.
It has been suggested that interleukin (IL)-18 plays a role in the development of inflammatory and fibrosing lung diseases. Associations of polymorphisms in the genes coding for IL-18 (IL18 /G-656T, C-607A, G-137C, T113G, C127T) and its receptor (IL18R1 /C-69T) with coal workers' pneumoconiosis (CWP) were studied in 200 miners who were examined in 1990, 1994 and 1999. Coal-dust exposure was ass...
متن کاملIL18 and IL18R1 polymorphisms, lung HRCT and fibrosis: a longitudinal study in coal miners
Rachel Nadif, Margaret Mintz, Jacqui Marzec, Anne Jedlicka, Francine Kauffmann, Steven R. Kleeberger, 1 INSERM U780, Villejuif, France 2 Université Paris Sud, Faculté de médecine, IFR69, Villejuif, France 3 Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD USA 4 Laboratory of Respiratory Biology, National Institute of Environmental Health Sciences, Research Triangle Par...
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Longitudinal loss of lung function in 1677 coal-miners from five British collieries has been calculated from the results of serial cross-sectional epidemiological surveys and compared with measured concurrent individual respirable dust exposures and partially estimated previous cumulative exposures. Loss of forced expired volume in one second (FEV1) over approximately 11 years was found to incr...
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In a study of coal-miners suffering from lung cancer two features of special interest are recorded. The difficulties in diagnosis are illustrated by case reports. The two-year survival rate after surgical removal of the tumour is significantly better in coal-miners than in non-miners. After operation 87% of coal-miners were alive two years later, compared with only 36% of other patients operate...
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BACKGROUND Oxidative stress plays a major role in the pathogenesis of interstitial lung diseases. The antioxidant enzymes glutathione S-transferases (GST) and manganese superoxide dismutase (MnSOD) are important components of lung defence against oxidative stress, and polymorphisms in the genes which regulate their expression may represent important disease modifiers. METHODS A matched case-c...
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ژورنال
عنوان ژورنال: European Respiratory Journal
سال: 2006
ISSN: 0903-1936,1399-3003
DOI: 10.1183/09031936.00031506